Recent Publications

Nag, S., Sommese, R.F., Ujfalusi, Z., Combs, A., Langer, S., Sutton, S., Leinwand, L.A., Geeves, M.A., Ruppel, K.M. and Spudich, J.A. (2015). Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function. Science Advances, in press.

Spudich, J.A., Aksel, T., Bartholomew, S.R., Nag, S., Kawana, M., Choe Yu, E., Sarkar, S.S., Sung, J., Sommese, R.F., Sutton, S., Cho, C., Adhikari, A.S., Taylor, R., Liu, C., Trivedi, D. and Ruppel, K.M. (2015).  Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human b-cardiac myosin. J Exp Biol, in press.

 Sung, J., Nag, S., Mortensen, K.I., Vestergaard, C.L., Sutton, S., Ruppel, K., Flyvbjerg, H. and Spudich, J.A. (2015). Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules. Nat Commun6:  Article number: 7931. doi:10.1038/ncomms8931. PMID: 26239258.

 Hariadi, R.F., Sommese, R.F., Adhikari, A.S., Taylor, R.E., Sutton, S., Spudich, J.A. and S. Sivaramakrishnan, S. (2015).  Mechanical Coordination in Motor Ensembles Revealed Using Engineered Artificial Myosin Filaments. Nature Nanotechnology 10:696-700. doi: 10.1038/nnano.2015.132.  Epub 2015 Jul 6.  PMID: 26149240.

Aksel, T., Choe Yu, E., Sutton,S., Ruppel, K.M. and Spudich, J.A. (2015).  Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector.  Cell Reports 11:910-920. doi: 10.1016/j.celrep.2015.04.006. Epub 2015 Apr 30. PMID: 25937279.

Spudich, J.A. (2015).  The Myosin Mesa and a Possible Unifying Hypothesis for the Molecular Basis of Human Hypertrophic Cardiomyopathy.  Biochem Soc Trans43:64-72. doi: 10.1042/BST20140324. PMID: 25619247.

Gupte, T.M., Hague, F., Gangadharan, B., Sunitha, M.S., Mukherjee, S., Anandhan, S., Rani, D.S., Mukundan, N., Jambekar, A., Thangaraj, K., Sowdhamini, R., Sommese, R.F., Nag, S., Spudich, J.A. and Mercer, J.A. (2015).  Mechanistic Heterogeneity in Contractile Properties of a-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies.  J Biol Chem 290:7003-7015.

Spudich, J.A. (2014). Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases.  Biophys J106:1236-1249.

Mendez, D., Lane, T.J., Sung, J., Sellberg, J., Levard, C., Watkins, H., Cohen, A.E., Soltis, M., Sutton, S., Spudich, J.A., Pande, V., Ratner, D. and Doniach, S. (2014).  Observation of Correlated X-ray Scattering at Atomic Resolution.  Phil. Trans. R. Soc. B 369:20130315.

 Sommese, R.F., Nag, S., Sutton, S., Miller, S.M., Spudich, J.A., and Ruppel, K.M. (2013). Effects of Troponin T Cardiomyopathy Mutations on the Calcium Sensitivity of the Regulated Thin Filament and the Actomyosin Cross-bridge Kinetics of Human b-cardiac Myosin.  PLoS One. Dec 18;8(12):e83403. doi: 10.1371/journal.pone.0083403.

Sommese, R.F., Sung, J., Nag, S., Sutton, S., Deacon, J.C., Choe, E., Leinwand, L.A., Ruppel, K., and Spudich, J.A. (2013). Molecular Consequences of the R453C Hypertrophic Cardiomyopathy Mutation on Human b-cardiac Myosin Motor Function.  Proc Natl Acad Sci USA110:12607-12612.

Elting, M.W., Leslie, S.R., Churchman, L.S., Korlach, J., McFaul, C.M., Leith, J.S., Levene, M.J., Cohen, A.E., and Spudich, J.A. (2013). Single-molecule Fluorescence Imaging of Processive Myosin with Enhanced Background Suppression Using Linear Zero-mode Waveguides (ZMWs) and Convex Lens Induced Confinement (CLIC).  Opt Express. 21:1189-1202.