Over the last several decades we have studied the structure and function of the myosin family of molecular motors in vitro and in vivo. That work has led us to our current focus on the human cardiac sarcomere and the molecular basis of hypertrophic and dilated cardiomyopathy.
Our research interests have included the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, and the roles of the myosin family of molecular motors in eukaryotic cells. We have developed multiple new tools, including in vitro motility assays taken to the single molecule level using laser traps. We are now applying these tools toward an understanding of normal and diseased human cardiac function.